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Effective against mainly Gram-negative and some gram-positive bacteria that produce beta — lactamase and are resistant to most antibiotics and sulfonamides.
- Data on cases of ofloxacin overdose are extremely limited.
- Bone and Joint Infections.
- Ofloxacin does not destroy protective commensals, such as lactobacilli in the vagina, which prevent its colonization by other microbes.
- Nocardia asteroides, anaerobic bacteria e.
- Ofloxacin concentrate in different tissues.
Ofloxacin — one of the last fluoroquinolones produced currently. Besides piperazinolovogo ring and a fluorine atom, there is also a ofloxacin oxazine ring. Ofloxacin is characterized by the best absorption and bioavailability of all fluoroquinolones except pefloxacin. Ofloxacin has a Online bactericidal action through a unique mechanism, namely: Ofloxacin very quickly kills bacteria. With its unique dual mechanism of action and negligible frequency stability.
Ofloxacin kills bacteria in all phases of the exchange, that is rapidly growing, slow-growing or slow-metabolizing penicillins, cephalosporins and aminoglycosides destroy a rapidly multiplying bacteria. Ofloxacin, due to its unique post — antibiotic effect PAE, Floxin Generic Without Prescription Online, prevents the quick resumption of Floxin growth of bacteria even at concentrations below the MIC. Because of the generic high bioavailability and easy penetration, ofloxacin reach without high concentrations in the interstitial tissue fluid inside cells. Thus, it is extremely suitable for the treatment of infections caused by intracellular bacteria such as typhoid, gonorrhea and chlamydia.
There is a small amount of data that suggests that high doses can produce ofloxacin therapeutic concentrations in the CNS, thus advantageously used in its CNS infections. In comparative studies on oral therapy ofloxacin, ciprofloxacin was active against gram-positive bacteria as well and chlamydia and equally effective against gram-negative pathogens.
In practice, ofloxacin may be effective even against pathogens resistant to prescription quinolones, due to complete inhibition of both subunits of DNA — gyrase. There is a partial cross-resistance with other fluoroquinolones. Ofloxacin has a comprehensive range of actions, covering almost all aerobic bacterial pathogens at extremely low BMD.
Below are listed the IPC 90 for various microorganisms. Aerobic gram-negative bacteria It is also moderately sensitive to ofloxacin Pseudomonas spp. Mycobacterium tuberculosis, Mycobacterium leprae, Enterococcus faecalis. In most cases insensitive to ofloxacin: Nocardia asteroides, anaerobic bacteria e. Ofloxacin is only active against certain strains B.
Ofloxacin general information
After oral ofloxacin almost completely and rapidly absorbed from the gastro — intestinal tract. Eating and H 2 — blockers did not significantly affect the absorption. The rate Floxin absorption can be slowed down a little meal. On absorption of Online affect antacid comprising magnesium ions or aluminum aluminum and magnesium hydroxide. Peak concentrations and protein binding: Upon receiving single doses of 200 and 400 mg kontsentratstsii peak ranges from 2.
Ofloxacin is widely distributed to all prescriptions of the body. Upon without generic doses of therapeutic concentrations are achieved even in the central nervous system. Ofloxacin concentrate in different tissues.
Its content in lung tissues ENT — organs, muscle, liver, gallbladder and bile, and genito-urinary tract tissue than in the blood. Ofloxacin particularly well into the prostate gland.
Ofloxacin passes the placenta and passes into breast milk. The half-life in plasma of ofloxacin was 5 — 7 hours, and therapeutic concentrations in all tissues preserved for 12 — 24 hours. Its total dose remains active until hatching.
Thus, even after 24 hours of ofloxacin concentration in the urine of a few hundred times higher than the MIC of uropathogens. Therefore, ofloxacin is highly effective for the treatment of urinary tract infections any location. Ofloxacin is completely eliminated from the body, does not accumulate in it. In renal insufficiency, the dose must be reduced proportionally.
Ofloxacin has been successfully used to treat a wide variety of systemic infections, caused by susceptible to bacterial pathogens. Ofloxacin is especially shown in the following conditions: In addition, it should be given a metronidazole with which it is compatible to cover anaerobic microorganisms.
Ofloxacin in 1993 was recommended by the Center for Disease Control CDC, USA for use in the outpatient treatment of acute gynecological infections 400 mg ofloxacin 2 times a day for 14 days in combination with metronidazole 500 mg 2 times a day, or clindamycin 450 mg 4 times a day. Ofloxacin does not destroy protective commensals, such as lactobacilli in the vagina, which prevent its colonization by other microbes. Therefore, the risk of superinfection becomes very small. Ofloxacin is highly effective against all uropathogens, frequent or rare, and also against multiresistant microorganisms of any localization.
The use of Online with prostatitis, urethritis caused by chlamydia and other diseases of the urinary tract is Without to the FDA, USA. Sexually transmitted diseases by. Due to the high efficacy against N, Floxin Generic Without Prescription Online. Ofloxacin may be effective and chancroid, although this is not enough data. All these diseases are generic with Floxin with excellent results. Infections of ENT — organs. The use of ofloxacin was accompanied by an extremely high percentage of bacteriological and clinical cure.
In the treatment of infections of ENT — organs that fluoroquinolone understood better than others. However, after general anesthesia of the patient can be transferred to the treatment ofloxacin. Ofloxacin can be used as a prescription to the beta — lactams and aminoglycosides. Bone and Joint Infections.
Ofloxacin is highly effective in infections of bones and joints, since it reaches high concentrations of therapeutic and even kills slowly metabolizing bacteria. Infections gastro — intestinal tract and enteric fever. Ofloxacin is effective against all of the gastro — intestinal pathogens and is highly active against Salmonella. It reaches high intracellular concentrations are rapidly and radically eliminate Salmonella typhi. From — due to poor absorption from the gastro — intestinal tract, in these conditions is preferred parenteral therapy. Ofloxacin — as a monotherapy or in combination with aminoglycosides — has a pronounced positive effect, Floxin Generic Without Prescription Online.
While improving the condition of the patient is recommended switching to tablet form of ofloxacin. The recommended dose for generic infections of the without tract and the gastro — intestinal tract is 200 mg twice a day. In other infections we recommend taking 200 to 400 mg twice daily depending on the severity and form Prescription the infection. The dose of 400 mg twice daily may be required in severe, complicated, or a problem caused by the microflora streptococci infections.
According to the recommendations approved by the FDA ofloxacin used in cervicitis and urethritis caused Online chlamydia at a dose of Floxin mg twice a day for at least 7 days, prostatitis, caused by E, Floxin Generic Without Prescription Online.
There is information about the possibility of the appointment of ofloxacin 400 mg prescription generic uncomplicated urinary and respiratory tract infections, Floxin Generic Without Prescription Online. Infusion is indicated for the impossibility of oral therapy, at a dose of 200 to 400 Floxin slowly intravenously 2 times a day. If you have without renal impairment the dose should be reduced by half. Patients with severe renal impairment or Online hemodialysis or peritoneal dialysis is recommended to appoint 100 mg every other day.
The duration of therapy will vary depending on the severity and type of infection.
However, it is recommended to continue the treatment for 2 — 3 days after the disappearance of disease symptoms and signs. In cystitis the duration of therapy may be only 3 days. In typhoid fever requires 10 — 14 — day therapy at 200 mg twice a day. Data on cases of ofloxacin overdose are extremely limited.